Can the salivary urea and stimulated saliva concentration be a marker of periodontal diseases in opioid users? A case-control study

Introduction& Aim: Microbial plaque is the primary cause of periodontal diseases, and smoking opioid addiction can accelerate microbial formation disease progression. Adequate saliva flow salivary urea concentration are important parameters for a healthy periodontium. In this study, relationship between Periodontal Diseases History was investigated by measuring Salivary Urea Stimulated Saliva Concentration.Materials & methodsThis case-control study conducted on 240 patients (120 cases 120 controls) in 2021 referred to treatment centers dental clinic Iran, Birjand. The control case groups were matched terms age. Demographic, base data, clinical examination results collected checklist. Data analyzed using SPSS 19 one-way ANOVA chi-square tests. P-value <0.05 considered as significance level.ResultsPeriodontitis severity significantly higher group than (P-value = 0/000). increased both with an increase periodontitis 0/003 0/000 group), but there no significant stimulated rate these two (P-value>0.05).ConclusionFollowing use opioids, decreases, exacerbation disease, increases. Therefore, it seems that analysis parameters, including concentration, be useful diagnosis not directly related use.